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| Id: | 21622
| | Autor: | Mayer, R. L; Eisman, P. C; Geftic, S; Konopka, E. | | Título: | The antituberculosis and antileprosy activity of disubstituted thiocarbanilides.
| | Fonte: | Int. J. Lepr;27(1):8-25, Jan.-Marc. 1959. ilus, tab, graf.
| | Resumo: | On the basis of the taxonomic relationship between mycobacteria and fungi, numerous thioureas known to be potent fungicides were tested for their activity against mycobacteria. Many disubstituted representatives of this group of drugs, among them especially certain thiocarbanilides, demonstrated excellent in vitro and in vivo activities against a virulent strain of M. tuberculosis, and Su 1906 showed moderate activity against murine leprosy. Activity of the thiocarbanilides depends on the nature of the substituents in the R and R1 positions. In the example given, those with 3 to 5 carbon atoms possessed most activity. Results of treatment of experimental tuberculosis in mice and guinea-pigs under various conditions are reported. Combinations of suboptimal doses of Su 1906 with suboptimal doses of isoniazid or of streptomycin resulted in considerable enhancement of activity. The tubercle bacillus developed, slowly, only a low grade of resistance to Su 1906, and when the latter was used in combination the rapid and high resistance to streptomycin was appreciably delayed, and that to isoniazid was almost completely suppressed. Su 1906 has been found to have activity against the photochromic "atypical" mycobacteria in some cases more than INH or streptomycin. Not a great deal of stress is laid on the results of treatment of murine leprosy, because that is not a good test object for assessing activity of drugs for human leprosy. Clinical reports on the action of certain thiocarbanilides in human leprosy are encouraging. However, the chemotherapeutic assessment of new drugs, particularly in diseases like tuberculosis and leprosy, requires prolonged observation in all types of the infection. It is not only the immediate effectiveness of a new drug, or its lack of toxicity, or the paucity of untoward side effects, which make its introduction worthwhile. Factors such as persistence of beneficial effects, absence of rapidly-acquired resistance, and compatibility with other types of therapy are of equal importance. For the benefit of those who are in need of this therapy, it is to be hoped that future experience will prove that all the above conditions will be fulfilled by this new thiocarbanilide class of antituberculosis and antileprosy compopunds. (AU).
| | Descritores: | HANSENIASE TUBERCULOIDE/clas
HANSENIASE TUBERCULOIDE/diag
HANSENIASE TUBERCULOIDE/prev
HANSENIASE/diag
HANSENIASE/prev
| | Meio Eletrônico: | - .
| | Localização: | BR191.1 |
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